Sulphonamides, sulphasalazine, sulfasalazine

SULPHASALAZINE (sulphonamide)

also known as salazopyrin, sulfasalazine and azulfidine

Adverse Drug Reaction (ADR) reports include insomnia, mental depression, hallucinations and psychosis.

There have been reports of terrifying nightmares in medical publications

Psychosis is a known and recorded side effect of sulphonamide drugs yet the term does not appear in the patient information.

It is vital not to become dehydrated when taking sulfasalazine.

The Pharmacia and Upjohn data sheet stated:

Sulphasalazine (salazopyrine) is prescribed for maintaining remission in ulcerative colitis for the treatment of active Crohn's disease.

On the manufacturers data sheet is a statement "A PATIENT INFORMATION LEAFLET SHOULD BE SUPPLIED SPECIFICALLY ADVISING PATIENTS ON BLOOD DYSCRASIAS" It recommends blood tests and "the patient should also be counselled to report immediately with any sore throat, fever, malaise or unexpected non specific illness."

In medical literature it has been stressed that patients should be instructed regarding the importance of adequate fluid intake"

 

Reporting Adverse Drug Reactions (ADRs)

It is well known that serious side effects of medicines are under reported and the UK regulatory body the Medicines and Healthcare Regulatory Agency (MHRA) estimate less than 10% of serious ADRs are reported.

If you are, for no apparent reason, feeling mentally distressed, it may be caused by starting or stopping medication, due to a changed dose, withdrawal effects, interactions with other drugs, or following surgery. You can request a list of drugs used pre surgery and during surgery and those for pain or infection to be taken later.

Some drugs must not be stopped suddenly

If you have suffered psychiatric, neurological or physical adverse drug reactions (ADRs) please report them. There may be adverse effects not mentioned on the patient leaflets (PILs) or data sheets. (SPCs)

You should be given a patient information leaflet (PIL) for all drugs prescribed, either as you are discharged from hospital, or if the pharmacy supplies you from a bulk supply of pills. (EU Directive 1997)

Please report Adverse Drug Reactions (ADRs) to:

UK - Yellow Card Reporting for Patient and Health Professional reports of Adverse Drug Reactions you can report to the MHRA using the link above or call them 0808 100 3352 10am - 2pm Monday to Friday

USA and worldwide - to the Food and Drug Administration for Patients and Healthcare Professionals

Universal free, independent drug safety website - Rxisk

 

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