Personalised MedicineAt last in March 2022 a promise for Personalised Medication Prescribing. This should dramatically reduce harm done to many by using medication they cannot tolerate, or does nothing to improve their condition. Recommendations on DPD testing prior to treatment with fluorouracil, capecitabine, tegafur and flucytosineNHS ENGLANDClinical Commissioning Urgent Policy Statement Pharmacogenomic testing for DPYD polymorphisms with fluoropyrimidine therapies [URN 1869] (200603P)https://www.england.nhs.uk/wp-content/uploads/2020/11/1869-dpyd-policy-statement.pdf Pharmacogenomic testing for DPYD polymorphisms which cause dihydropyrimidine dehydrogenase (DPD) deficiency is recommended to be available through routine commissioning as a pre-treatment screening test prior to the administration of fluoropyrimidinebased therapies through routine commissioning within the criteria set out in this document. Information about pharmacogenomic testing for DPYD polymorphisms with fluoropyrimidine therapies On 30 April 2020, EMA recommended that patients should be tested for the lack of the enzyme dihydropyrimidine dehydrogenase (DPD) before starting cancer treatment with fluorouracil given by injection or infusion (drip) or with the related medicines, capecitabine and tegafur. As treatment for severe fungal infections with flucytosine (another medicine related to fluorouracil) should not be delayed, testing patients for DPD deficiency before they start treatment is not required. Patients who completely lack DPD must not be given any fluorouracil medicines. For patients with partial deficiency, the doctor may consider starting cancer treatment at lower doses than normal or stoppingflucytosine treatment if severe side effects occur. https://www.england.nhs.uk/wp-content/uploads/2020/11/1869-dpyd-policy-statement.pdf
Personalised MedicineAt last in March 2022 a promise for Personalised Medication Prescribing. This should dramatically reduce harm done to many by using medication they cannot tolerate, or does nothing to improve their condition. A Detailed report just published March 2022 by the An article in The Guardian Experts push for genetic testing to personalise drug prescriptions explains the benefits, as About 6.5% of UK hospital admissions are caused by adverse drug reactions, while most prescription medicines only work on 30% to 50% of people. APRIL has been promoting the use of genetic testing for many years - Click here for a talk by Professor Sir Munir Pirmohamed, Chair of the Working Group on Personalised Prescribing, speaking at our conference
DOCTORS - NURSES - PSYCHIATRISTS & Non Medical Prescribers IMPORTANT INFORMATION about iatrogenic psychiatric adverse drug reactions. Many medicines you may have prescribed CAN CAUSES DEPRESSION AND EVEN LEAD TO SUICIDE. Professor Munir Pirmohamed and other researchers stated " In recent years there has been growing concern that certain prescribed medicines may be associated with psychiatric adverse drug reactions such as depression, non-fatal self-harm and suicide" Click on the heading for the published research. Professor Sir Munir Pirmohamed with research colleagues published the following and you can click here for the full paper: Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011 In the above research information there is a table showing: Rates of Yellow Card adverse reports per million prescriptions dispensed for the top 20 drugs with the highest number of adverse reports for depressive disorders, non-fatal suicidal behaviour and suicide Prescribed pharmaceutical medicines include: Rimonabant Isotretinoin Mefloquine Etonogestrel Sibutramine Levonorgestrel Desogestrel Levetiracetam Please read the Royal College of Anaethetists information about 'Delirium and Confusion after Anaesthesia' Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011 The Imperial College study as published in the Royal Society of Medicine journal may have escaped your notice.
ADR hospital admission statistics to 2010 (as published by the Royal Society of Medicine)
If you were unable to attend our conferences, you may still listen to many Professors and academics you will rarely have the opportunity to her...revue this list of speakers Professor Heather Ashton - expert Clinical Pharmacologist who ran a Benzodiazepine Withdrawal Clinic for Many years and produced the Ashton Manual to help clinicians assist their patients and prevent the harm of too sudden withdrawal from prescribed drugs that cause dependence. Professor Munir Pirmohamed - expert in the area of Personalised Medicine now being promoted. Personalised Medicine - March 2022 Breaking NewsAt last in March 2022 a promise for Personalised Medication Prescribing. This should dramatically reduce harm done to many by using medication they cannot tolerate, or does nothing to improve their condition. A Detailed report just published March 2022 by the Now listen to wise words that could inrease your ability to save suffering here on videos hosted on our Vimeo site. Professor Simon Maxwell - Clinical Pharmacologist is involved in educating medical students and was always concerned about the need for more information about Adverse Drug Reactions. A new Prescribing Safety Assessment examination for medical students, may ensure some graduates since 2016 will be better prepared than many of their predecessors. The GMC guidelines on Medical Education 'Tomorrow's Doctors' had excluded Clinical Pharmacology and Therapeutics in the 'Integrated Medicine' model of education since the early 90's. https://prescribingsafetyassessment.ac.uk/
Emeritus Professor of Anaesthesiology Anita Holdcroft - anaesthetist & academic researcher speaks of a case study in the British Medical Journal of Co-amoxiclav acute psychosis, an adverse drug reactions (ADR) many would have found surprising. Hear an interesting discussionwith leaders in the field of Medicines Regulation,Pharmacovigilance,Clinical Pharmacology,Anaesthesiology and Psychiatry,in this eye opening discussionAndrew Herxheimer renowned Clinical Pharmacologist Founder of the Drug and Therapeutics Bulletin , Professor Joanna Moncrieff, Professor Simon Maxwell , Charles Medawar, Professor David Healy, Dr Anita Holdcroft in a panel session at our last conference. Andrew Herxheimer was a champion of evidence-based medicine Please listen to some or all the wise words of experts in the field of Clinical Pharmacology, anaesthetics, pharmacogenetics here on videos hosted on our Vimeo site. Learn from the valued experience of the above speakers plus Professor David Healy - psychiatrist. Charles Medawar academic researcher - Nigel Meadow, Manchester City Coroner - Dr Ben Goldacre author of Bad Science. Please also read this vital information to prevent harm from
|